Peptides poob phaus feem ntau pab kom poob phaus los ntawm kev tswj kev qab los noj mov, metabolism, thiab rog rog. Lawv txoj kev ua tau zoo yuav tsum muaj kev noj qab nyob zoo thiab lawv feem ntau yog cov tshuaj noj; lawv yuav tsum tsis txhob siv dig muag.
Peptides poob yog ib chav kawm ntawm bioactive peptides uas ua rau lub cev metabolic txoj hauv kev, tshwj xeeb tshaj yog GLP-1 receptor agonists (xws li liraglutide, smegglutide, thiab telpoglutide). Lawv tsis ncaj qha "kub rog," tab sis theej pab tswj qhov hnyav los ntawm ntau lub tshuab:
Ncua Kev Noj Qab Haus Huv thiab Txhim Kho satiety: Peptides poob phaus qhib GLP-1 receptors hauv lub hlwb (xws li hauv hypothalamus), xa cov cim "satiety" rau lub cev thiab txo qis kev xav rau cov khoom noj uas muaj calorie ntau ntau. Lawv kuj ua rau lub plab zom mov qeeb, tso cai rau cov zaub mov nyob hauv lub plab ntev dua, yog li ua kom ntev satiety.
Kev Tswj Xyuas Metabolism thiab Txhim Kho Insulin rhiab heev: Lawv tuaj yeem txhawb kev tsim cov tshuaj insulin, inhibit glucagon tso tawm, stabilize cov ntshav qab zib, txo cov ntshav qab zib tom qab hloov pauv, thiab yog li txo qhov kev pheej hmoo ntawm cov rog. Qee cov peptides kuj tuaj yeem txhim kho insulin tsis kam, ua rau lawv tshwj xeeb tshaj yog rau cov neeg mob metabolic syndrome.
Txhawb kev rog rog thiab kev siv zog: Qee cov peptides tuaj yeem ua kom cov lipases, ua kom nrawm nrawm ntawm triglycerides rau hauv cov roj fatty acids dawb; Cov kev tshawb fawb kuj tau pom tias lawv tuaj yeem txhawb kev hloov pauv ntawm cov rog dawb rau cov rog xim av, txhim kho thermogenesis, thiab nce basal metabolic tus nqi.
Cov txiaj ntsig tseem ceeb hauv kev poob phaus, tab sis txawv ntawm tus neeg rau ib tus neeg: Cov ntaub ntawv kho mob qhia tau tias smegglutide ua rau qhov hnyav poob ntawm kwv yees li 15%, telpoglutide ua tiav txog 20.9% (SURMOUNT-1 sim), thiab liraglutide ntawm ib hnub koob tshuaj 1.8 mg6 ua rau poob phaus 2 kg. Txawm li cas los xij, cov txiaj ntsig tau cuam tshuam los ntawm tus kheej cov metabolism, kev noj haus, thiab kev tawm dag zog.