Cov hom loj ntawm qhov hnyav -peptides poob suav nrog GLP-1 receptor agonists (xws li smegglutide thiab liraglutide), kev loj hlob hormone secretagogues (xws li CJC-1295), thiab tshiab peptides poob (xws li acetyl hexapeptide-39). Ntawm cov no, GLP-1 peptides yog siv dav tshaj plaws hauv kev kho mob thiab muaj qhov pom tseeb qhov hnyav.
Cov peptides no siv lawv cov teebmeem los ntawm kev sib txawv mechanisms:
GLP-1 receptor agonists: xws li smegglutide, liraglutide, thiab dulaglutide, tuaj yeem ua raws li cov kev cuam tshuam ntawm plab hnyuv hormone GLP-1, txo qis qab los noj mov, ncua kev zom zaub mov, ua kom satiety, thiab txhawb cov insulin secretion los tswj cov ntshav qab zib. Cov tshuaj no tau pom zoo los ntawm National Medical Products Administration rau kev tswj qhov hnyav mus sij hawm ntev thiab tsim nyog rau cov neeg mob uas muaj BMI Ntau dua lossis sib npaug li 27 thiab teeb meem lossis BMI Ntau dua lossis sib npaug li 30.
Kev loj hlob hormone- zais peptides, xws li CJC-1295, txhawb lub caj pas pituitary kom tso tawm cov tshuaj hormones loj hlob, txhawb kev rog rog thiab ua kom cov leeg nqaij. Lawv feem ntau yog siv los kho lub cev rog thiab txhim kho metabolic.
Novel functional slimming peptides, xws li acetyl hexapeptide-39, tau thov kom txo cov cellulite thiab muab lub cev contouring hauv zos, tab sis tam sim no cov pov thawj tshawb fawb tau txwv, thiab lawv txoj kev nyab xeeb yuav tsum muaj kev txheeb xyuas ntxiv.
Qhov tseem ceeb, enoglulide, lub ntiaj teb thawj cAMP-biased GLP-1 receptor agonist, tau pom zoo nyob rau lub Peb Hlis 2026 rau kev tswj mus sij hawm ntev ntawm cov laus / rog rog. Nws tau pom tias muaj kev ua tau zoo hauv cov ntsiab lus ntawm kev poob phaus (nruab nrab 15.4%), kev ua siab ntev, thiab kev txhim kho hauv cov hlab plawv thiab cov kab mob metabolic, nrog rau kev mob plab me me thiab kev kho tus nqi tsuas yog 2%.
Tsis tas li ntawd, telpolide thiab masidolide, raws li "bifunctional" receptor agonists, tuaj yeem ua rau tib lub sijhawm ua rau GLP-1 thiab GIP receptors, uas ua rau muaj zog yuag poob (txog 15% -22%), ua rau lawv tshwj xeeb tshaj yog haum rau cov neeg uas xav kom poob phaus ntau. Masidolide kuj muaj qhov zoo ntawm kev ua rau lub plab zom mov.